The Xindi-Insectoids are human-sized sentient bugs that have a lifespan of a dozen years. I’m no scientist, but wouldn’t a bug with an exoskeleton that big effectively be unable to move due to the weight of that same exoskeleton? Maybe because it’s an alien bug person it’s got an ultralight exoskeleton. Oh well, check out their Xindi-Insectoid Warship that they use to attack the poor humans of the 22nd century in their woefully inadequate United Earth NC-class.
Just so the giant space bugs don’t have all the fun, by the 24th century we have the Zalkonians using their Zalkonian Warship to asphyxiate people with their choking beam. That’s right, it’s a beam that can choke you from thousands of kilometers away inside your own space ship. I guess that makes sense, I mean, why incinerate someone on their fancy ship with your beams of amplified light when you can just choke them to death and then walk on board their ship and take all their stuff?
Lastly we have the Cardassians (think people with scaly skin and the pallor of a wax sculpture) and their semi-sentient (or is that conscious) Cardassian ATR-4107 missile.
The Cords that Bind 